In Vivo Imaging
We use real time in vivo imaging to monitor disease progression and measure cellular response to therapies in live animals. We developed bioluminescence reporter mice for monitoring TGF-beta signaling. In collaboration with pioneers in the field, we employ near-infrared fluorescence imaging to monitor neurovascular damage and blood-brain barrier leakage. These imaging techniques allow longitudinal and noninvasive monitoring to assess disease progression and therapeutic effects in live animals.